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Did you mean avt and cardiovascular diseases (76 results)?
AATF/Che-1 localizes to paraspeckles and suppresses R-loops accumulation and interferon activation in Multiple Myeloma.
Bruno T, Corleone G, Catena V, Cortile C, De Nicola F, Fabretti F, Gumenyuk S, Pisani F, Mengarelli A, Passananti C, Fanciulli M. Bruno T, et al. EMBO J. 2022 Nov 17;41(22):e109711. doi: 10.15252/embj.2021109711. Epub 2022 Aug 5. EMBO J. 2022. PMID: 35929179 Free PMC article.
Paraspeckle assemblies participate in R-loop resolution and preserve genome stability, however, the main determinants of this mechanism are still unknown. This study finds that in Multiple Myeloma (MM), AATF/Che-1 (Che-1), an RNA-binding protein fundamental to transcriptio …
Paraspeckle assemblies participate in R-loop resolution and preserve genome stability, however, the main determinants of this mechanism are …
A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.
Kaiser RWJ, Ignarski M, Van Nostrand EL, Frese CK, Jain M, Cukoski S, Heinen H, Schaechter M, Seufert L, Bunte K, Frommolt P, Keller P, Helm M, Bohl K, Höhne M, Schermer B, Benzing T, Höpker K, Dieterich C, Yeo GW, Müller RU, Fabretti F. Kaiser RWJ, et al. Sci Rep. 2019 Jul 30;9(1):11071. doi: 10.1038/s41598-019-47552-3. Sci Rep. 2019. PMID: 31363146 Free PMC article.
Recent data showed that AATF is essential for ribosome biogenesis and plays a role in rRNA maturation. ...Furthermore, AATF binds to mRNAs encoding for ribosome biogenesis factors as well as snoRNAs. ...
Recent data showed that AATF is essential for ribosome biogenesis and plays a role in rRNA maturation. ...Furthermore, AATF bi …
Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma.
Bruno T, De Nicola F, Corleone G, Catena V, Goeman F, Pallocca M, Sorino C, Bossi G, Amadio B, Cigliana G, Ricciardi MR, Petrucci MT, Spugnini EP, Baldi A, Cioce M, Cortese G, Mattei E, Merola R, Gianelli U, Baldini L, Pisani F, Gumenyuk S, Mengarelli A, Höpker K, Benzing T, Vincenzi B, Floridi A, Passananti C, Blandino G, Iezzi S, Fanciulli M. Bruno T, et al. Blood Adv. 2020 Nov 24;4(22):5616-5630. doi: 10.1182/bloodadvances.2020002566. Blood Adv. 2020. PMID: 33186461 Free PMC article.
This pathology exhibits an enormous heterogeneity resulting not only from genetic alterations but also from several epigenetic dysregulations. Here we provide evidence that Che-1/AATF (Che-1), an interactor of RNA polymerase II, promotes MM proliferation by affecting chrom …
This pathology exhibits an enormous heterogeneity resulting not only from genetic alterations but also from several epigenetic dysregulation …
Apoptosis antagonizing transcription factor protects renal tubule cells against oxidative damage and apoptosis induced by ischemia-reperfusion.
Xie J, Guo Q. Xie J, et al. J Am Soc Nephrol. 2006 Dec;17(12):3336-46. doi: 10.1681/ASN.2006040311. Epub 2006 Oct 25. J Am Soc Nephrol. 2006. PMID: 17065240
AATF is expressed in several organs and tissues, including the kidney. ...AATF may represent a potential candidate for therapeutic application in IRI....
AATF is expressed in several organs and tissues, including the kidney. ...AATF may represent a potential candidate for therape …
Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy.
Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, Sorino C, Ponzoni M, Bossi G, Federico V, La Rosa F, Ricciardi MR, Lesma E, De Meo PD, Castrignanò T, Petrucci MT, Pisani F, Chesi M, Bergsagel PL, Floridi A, Tonon G, Passananti C, Blandino G, Fanciulli M. Desantis A, et al. EMBO J. 2015 May 5;34(9):1214-30. doi: 10.15252/embj.201489920. Epub 2015 Mar 14. EMBO J. 2015. PMID: 25770584 Free PMC article.